Embarrassing experience Essay Example

Embarrassing experience Essay Example Embarrassing experience Essay Embarrassing experience Essay Auntie Liana! I stepped in the house in an elated mood of visiting my aunts house. But as I stepped in, I soon realized that something had gone wrong, the atmosphere was awkward. My aunt was talking about her favorite idol in enthusiasm, but the others, my cousins having awkward expression on their face , not knowing how to react to my aunts sudden speech. This reminds me of my first time bringing my friends home. It was an unforgettable experience. That day, after school, I brought my friends to my new house which had been renovated recently. We chatted happily along the pathway walking towards my house. After they reached my house, greeted my mother, they went to my room for heart-to- heart session that I had long-awaited for. We sat in a circle, each hugging a cushion, sat comfortably. With a happy mood, we started to share top secrets which was hidden in our heart. Just then, my mum barged in our room, squeeze into the circle we formed and Joined our conversation. She said in an excited way Im the great fans of cowboys!!!!! I still remembered how they dance!!! Just then, she stood up and started aiming with her weird, funny and old-style movement. We were all shocked and amused but her action and do not know how to react. My mums action let me blushed and felt so embarrass that I hope could find a hole and hide in it. Doing nothing, but we Just tried to enjoy her performance. The day ended in an awkward atmosphere. Remembering my experience, I could not help but smile. Realized that everybody experience this. Although the action of my mum made me felt embarrass but this is also her way to express her love. I will never forget this experience.

A History of United Nations Missions in Africa

A History of United Nations Missions in Africa The United Nations (UN) conducts a number of peacekeeping missions throughout the world. Beginning in 1960, the UN began missions in various countries in Africa. While just one mission occurred through the 1990s, turmoil in Africa escalated and the majority of missions were run from 1989 on. Many of these peacekeeping missions were the result of civil wars or ongoing conflicts in African countries, including Angola, the Congo, Liberia, Somalia, and Rwanda. Some of the missions were brief while others lasted years at a time. To confound things, some missions replaced previous ones as tensions in the countries escalated or the political climate changed. This period is one of the most dynamic and violent in modern African history and its important to review the missions that the UN carried out. ONUC -  UN Operations in the Congo Mission Dates: July 1960 through June 1964Context: Independence from Belgium and the attempted secession of the Katanga province Outcome:  Prime Minister  Patrice Lumumba  was assassinated, at which point the mission was expanded. The Congo retained the secessionist province of Katanga and the mission was followed by civilian aid. UNAVEM I -  UN Angola Verification Mission Mission Dates:  January 1989 through May 1991Context:  Angolas lengthy civil war Outcome:  Cuban troops were withdrawn one month ahead of schedule, having completed their mission. The mission was followed by UNAVEM II (1991) and UNAVEM III (1995). UNTAG  -  UN Transition Assistance Group Mission Dates:  April 1990 through March 1990Context:  Angolan Civil War and Namibias transition to independence from South Africa Outcome:  South African troops departed Angola. Elections were held and a new constitution approved. Namibia joined the UN. UNAVEM II  -  UN Angola Verification Mission II Mission Dates:  May 1991 through February 1995Context:  Angolan Civil War Outcome:  Elections were held in 1991, but the results were rejected and violence escalated. The mission transitioned to UNAVEM III. UNOSOM I  -  UN Operation in Somalia I Mission Dates:  April 1992 through March 1993Context:  Somali Civil  War Outcome:  The violence in Somalia continued to escalate, making it difficult for UNOSOM I to deliver relief aid. The United States created a second operation, the Unified Task Force (UNITAF), to help UNOSOM I protect and distribute humanitarian aid. In 1993, the UN created UNOSOM II to replace both UNOSOM I and UNITAF. ONUMOZ  -  UN Operations in Mozambique Mission Dates:  December  1992 through December 1994Context:  Conclusion of the Civil War in Mozambique Outcome:  The ceasefire was successful. Mozambiques then government and the major rivals (Mozambican Nation Resistance, or RENAMO) demobilized troops. Those people who were displaced during the war were resettled and elections were held. UNOSOM II  -  UN Operation in Somalia II Mission Dates:  March 1993 through March 1995Context:  Somali Civil War Outcome:  After the Battle of Mogadishu in October 1993, the United States and several Western countries withdrew their troops from UNOSOM II. The UN voted to withdraw UN troops from Somalia after having failed to establish a ceasefire or disarmament. UNOMUR  -  UN Observer Mission Uganda-Rwanda Mission Dates:  June 1993 through September 1994Context:  Fighting between the Rwandan Patriotic Front (RPF, based in Uganda) and the Rwandan Government Outcome:  The Observer Mission encountered many difficulties in monitoring the border. These were  due to the terrain and the competing Rwandan and Ugandan factions. After the Rwandan genocide, the missions mandate came to an end and it was not renewed. The mission was succeeded instead by UNAMIR, which had already begun its operations in 1993.   UNOMIL  -  UN Observer Mission in Liberia Mission Dates:  September 1993  through September 1997Context:  The First Liberian Civil War Outcome:  UNOMIL was designed to support ongoing efforts by the  Economic Community of West African States (ECOWAS)  to bring an end to the Liberian Civil War and ensure fair elections. In 1997, elections were held and the mission terminated. The United Nations established a Peacebuilding Support Office in Liberia. Within a few years, the Second Liberian Civil War had broken out. UNAMIR -  UN Assistance Mission for Rwanda Mission Dates:  October 1993  through March 1996Context:  Rwandan Civil War between the RPF and the Rwandan government Outcome:  Due to the restrictive rules of engagement and an unwillingness from Western governments to risk troops in Rwanda, the mission did little to stop the Rwandan genocide (April through June 1994).   Afterward, UNAMIR did  distribute and ensure humanitarian aid. However, the failure to intervene in the genocide overshadows these significant although belated efforts. UNASOG  -  UN Aouzou Strip Observation Group Mission Dates:  May 1994 through June 1994Context:  Conclusion of the territorial dispute (1973-1994) between Chad and Libya over the Aouzou Strip. Outcome:  Both governments signed a declaration agreeing that Libyan troops and the administration had been withdrawn as previously agreed upon. UNAVEM III  -  UN Angola Verification Mission III Mission Dates:  February 1995 through June 1997Context:  Angolas Civil War Outcome:  A government was formed by the National Union for the Total Independence of Angola (UNITA), but all parties continued to import arms. The situation also deteriorated with the involvement of Angola in the Congo Conflict. The mission was followed by MONUA. MONUA  -  UN Observer Mission in Angola Mission Dates:  June 1997 through February 1999Context:  Angolas Civil War Outcome:  Fighting in the civil war resumed and the UN withdrew its troops. At the same time, the UN urged a continuation of humanitarian aid. MINURCA -  UN Mission in the Central African Republic Mission Dates:  April 1998 through February 2000Context:  Signing of the Bangui Accord between rebel forces and the Central African Republics government Outcome:  Dialogue between the parties continued and the peace was maintained. Elections were held in 1999 after several previous attempts. The UN mission withdrew. MINURCA was followed by a UN Peacebuilding Support Office in the Central African Republic. UNOMSIL  -  UN Observer Mission in Sierra Leone Mission Dates:  July 1998 through October 1999Context:  Sierra Leones Civil War (1991-2002) Outcome:  The combatants signed the controversial Lome Peace Agreement. The UN authorized a new mission, UNAMSIL, to replace UNOMSIL. UNAMSIL  -  UN Mission in Sierra Leone Mission Dates:  October 1999 through December 2005Context:  Sierra Leones Civil War (1991-2002) Outcome:  The mission was expanded three times in 2000 and 2001 as the fighting continued. The war ended in December 2002 and  UNAMSIL troops were slowly withdrawn. The mission was followed by the UN Integrated Office for Sierra Leone. This was created to consolidate the peace in Sierra Leone. MONUC  -  UN Organization Mission in the Democratic Republic of the Congo Mission Dates:  November 1999  through May 2010Context:  Conclusion of the  First Congo War   Outcome:  The Second Congo War began in 1998 when Rwanda invaded. It officially ended in 2002, but fighting by various rebel groups continued. In 2010, MONUC was criticized for not intervening to stop mass rapes near one of its stations. The Mission was renamed the UN Organization Stabilization Mission in the Democratic Republic of the Congo. UNMEE -  UN Observer Mission in Ethiopia and Eritrea Mission Dates:  June 2000  through July 2008Context:  A ceasefire signed by Ethiopia and Eritrea in their ongoing border dispute. Outcome:  The mission was ended after Eritrea imposed numerous restrictions that prevented an effective operation. MINUCI  -  UN Operation in  Cà ´te dIvoire Mission Dates:  May 2003 through April 2004Context:  Failed implementation of the  Linas-Marcoussis Agreement, which was to end the ongoing conflict in the country. Outcome:  MINUCI was replaced by the UN Operation in Cà ´te dIvoire (UNOCI). UNOCI is ongoing and continues to protect the people in the country and aid the government in disarmament and demobilization of former combatants. ONUB -  UN Operation in  Burundi Mission Dates:  May  2004 through December 2006Context:  Burundian Civil War Outcome:  The missions goal was to restore peace in Burundi and help establish a unified government. Pierre Nkurunziza was sworn in as President of Burundi in August 2005.  Twelve years of midnight-to-dawn curfews were finally lifted on the people of Burundi. MINURCAT -  UN Mission in the Central African Republic and Chad Mission Dates:  September  2007 through December 2010Context:  Ongoing violence in Darfur, eastern Chad, and northeastern Central African Republic Outcome:  The concern for civilian safety amidst activities by armed groups in the region prompted the mission. By the end of the mission, the government of Chad pledged that they would retain responsibility for protecting its citizens. After the termination of the mission, the UN Integrated Peacebuilding Office in the Central African Republic continued efforts to protect the people.   UNMIS  -  UN Mission in Sudan Mission Dates:  March 2005 through July 2011Context:  End of the Second Sudanese Civil War and signing of the Comprehensive Peace Agreement (CPA) Outcome:  The CPA between the Sudanese government and the Sudan Peoples Liberation Movement (SPLM) was signed, but it did not bring immediate peace. In 2007, the two groups came to another agreement and Northern Sudanese troops withdrew from Southern Sudan.   In July 2011, the Republic of South Sudan was formed as an independent country. The mission was replaced by UN Mission in the Republic of South Sudan (UNMISS) to continue the peace process and protect civilians. This started immediately and, as of 2017, the mission continues. Sources: United Nations Peacekeeping.  Past Peacekeeping Operations.

How this class has affected me Essay Example | Topics and Well Written Essays - 2000 words

How this class has affected me - Essay Example Moreover I was caused to accurately define my personal and professional roles in future practice. In this essay, I give a reflection of the course in light of the manner in which it has affected me. My reflection is based on a review and reference to the information within the readings of the course. In addition, I provide the justifications for the change of my professional roles and future plans based on the knowledge that I acquired during the course. Furthermore, I will give a detailed discussion on how the cause caused me to specifically decide to work with Child Protective Services. Anne Fadiman’s â€Å"The Spirit Catches You and You Fall Down† presents a narration of the struggles that a refugee family from Hmong culture in Laos. The book specifically describes how two different cultures collide. The scenario that is presented by the writer is within California’s health care system. In the book, the writer reveals the interaction between a Hmong child with her Doctors in America and demonstrates the social cultural problems and struggles in the provision of health care. Lia Lee is a favorite child and youngest of the Hmong family. The doctors find out that Lia is having a severe form of epilepsy. The author describes how cultural differences between the family and the American doctors acts to obstruct Lia’s treatment. ... This means that healthcare providers require understanding the culture of their patients and ensuring that it does not obstruct their moral and ethical roles of patient centered care. Barbara Myerhoff's â€Å"Number of Our Days† presents the work of a renowned anthropologist. Myerhoff was given a grant to investigate or study the process of human aging. As a result Myerhoff chose to base her study on elderly Jewish community from Venice in California. It is notable that the author and anthropologist decided that he would study and report on the indigenous community rather than on an exotic society. When reading Myerhoff’s story, I was changed by the ways in which she presents the lives and rituals of these Jewish and unique old people. More significant is the cultural value which enabled the old people to face and go through numerous problems and challenges of living. Among the problems that the author demonstrates that these old people had to face include poverty, lone liness, neglect, physical danger, poor and inadequate housing and poor health. Myerhoff’s story inspired me to play a role in helping people to overcome the problems that they face in their social environments and during care. The author depicts the agonies of aging in a manner which makes a reader to sympathize and have a desire to do something in alleviating human suffering. Through this book I appreciated the human spirit as indomitable. Moreover I was appreciative of the importance of cultural rituals in living and overcoming problems as presented by the author in wise yet funny approach. The above brief description of the two most influential readings on my life is a background to the illustration of how the anthropology cause affected me. At this point I need to

President Clinton's Crime Policy Essay Example | Topics and Well Written Essays - 500 words

President Clinton's Crime Policy - Essay Example He successfully stole the "War on Crime" idea and added it into his campaign, and rode it all the way to victory in the White House. However, Clinton soon put his money where his mouth was, and showed just how tough on crime he was going to be during his Presidency. Throughout the entirety of Clinton's administration he "consistently supported increased penalties and additional prison construction. The Violent Crime Control and Law Enforcement Act of 1994 provided state and municipal governments with $30 billion to add 100,000 new police officers, to build more prisons, and to employ more prison guards, as well as funding for crime prevention programs". This was just the start of Clinton showing how he was going to continue his programs against crime in our country. Another potentially surprising figure is that during Clinton's reign as President, 225,000 more jail inmates were put into prisons than during Regan's administration. Clinton took what was considered a more Republican ideal, and turned it swiftly to benefit his campaign, and he also came through with the promises he made during his time in office. Also, by "signing the Violent Crime Control Act and Law Enforcement Act of 1994, which provided prison construction funds to the states, President Clinton's policies had already helped shift funds from higher ed

Trying To Sell An IPod Essay Example for Free

Trying To Sell An IPod Essay Have you ever ridden a bus or the train feeling bored without no one to talk to and wishing that you were listening to something good? Have you ever got on a car or other public transport vehicle or went to a public place where the music that is playing is somewhat not your preference and you wished that you could somehow change the station? Have you ever heard your favorite music playing and wished that you could turn the dial up so that you could enjoy it more? Well wish no more because with an iPod you can do all these things and so much more.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   With todays busy and noisy world, every person tries to find a place where they can find peace to be able to concentrate and do what they have to do. This can be hard, which is why a lot of people choose to â€Å"lose† themselves in the world of music with their music players. Also, music most definitely kills boredom. There are a lot of times where you find yourself waiting in line without no one to talk to or waiting for someone to arrive and you find yourself standing there looking like an idiot without nothing to do. Other times you find yourself staring at those people with their own music players who looks like they are enjoying what they are hearing and it makes you want to listen to what they are listening to.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Digital music players are such popular devices right now because they make music and other files manageable and portable. You can see almost every teenager and young adults bobbing their heads with the beat of their music from their players. Adults also use this to play music, store files, and do other things like podcasting. â€Å"Podcasting are digital media files, such as audio or video, which are produced in a series† (Bertucci â€Å"What is Podcasting?†). Aside from listening to music, students can also find that an iPod has many other uses. An iPod can be used as a course content dissemination tool, recording tool, support tool, or a file storage and transfer (â€Å"Duke University iPod First Year Experience Final Evaluation Report†).   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   So you think that you do not need an iPod? Let me tell you why you should change your mind. There are a lot of digital music players out in the market today; however, they are all basically the same because they are all capable of playing music in different formats. So why iPod in particular? The first thing that a consumer looks for is quality. With an iPod, there is no need to worry because its producer, which is Apple, is a very trusted brand when it comes to technology (Evans â€Å"Apple Most Trusted US Brand†). The iPod series are very simple yet show a class of its own that not many companies can not produce. You can find whatever kind of player you need because every player that Apple produces fits every individuals needs.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Apple offers the iPod shuffle, iPod nano, iPod classic, and iPod touch. For those with limited budget and could settle for a memory that can hold only about 240 songs, an iPod shuffle is the best choice. The 1GB shuffle only costs $49 while the newer model with 2GB is at $69 (â€Å"iPod shuffle†). It comes in a variety of colors and with its size, no one will have any problem carrying it around. The iPod classic is probably the best choice among all the iPod products. At $249, it boasts of 160GB storage capability and a sleek design (â€Å"iPod classic†). This is enough to store all your favorite music or albums, as well as photos and podcasts, and other files that you need to carry around. An iPod is something for both the average consumer and the techies. It is simple to use and files can be stored with just a few steps yet it offers so much more to those who would like to take advantage of its full services. If money is not an issue for you and you are always on the go, then an iPhone may be the best to offer. It doubles as an iPod and a cellphone so that there is no need to carry two devices at one time. Having an iPhone lessens the probability that you might lose the other or both because you have too many things in your hand.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Imagine life without music. This will be what your life would be like without an iPod. It can become sad, boring, and quiet. Without it, you will be able to hear every other noise there is in the world, which will make it hard to concentrate. Another great thing about an iPod is that it can be a social tool. It can become something to talk about between friends or colleagues. It can be added to the long list of topics that guys can use to talk about with the girls they like. For girls, it can be something to do while trying to ignore a guy you do not want to talk to.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Many people argue that the iPod has become too commercial and the individuality is lost all together. However, people should realize and keep in mind that this is bound to happen because of its success. Other music players do not do well on the market simply because they can not beat the iPods features and looks. With its affordable price and unbeatable features, why would you settle for anything less? Everyone owning an iPod does not matter because what it does for you is more important. Works Cited Bertucci, Brian. â€Å"What is Podcasting?† About.com. 14 April 2008.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   http://podcasting.about.com/od/basics101/a/whatis.htm â€Å"Duke University iPod First Year Experience Final Evaluation Report.† June 2005. 14 April   Ã‚  Ã‚  Ã‚   2008 cit.duke.edu/pdf/reports/ipod_initiative_04_05.pdf Evans, Jonny. â€Å"Apple Most Trusted US Brand.† Macworld. 17 May 2007. 14 April 2008   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   http://www.macworld.co.uk/news/index.cfm?RSSnewsID=18062 â€Å"iPod classic.†Ã‚   Apple. 14 April 2008 http://www.apple.com/ipodclassic/ â€Å"iPod shuffle.† Apple. 14 April 2008 http://www.apple.com/ipodshuffle/

Creationsim vs. Evolution :: Science Religion Essays

Creationsim vs. Evolution Intro Who or what really is our greatest of great ancestors? Most major religions and early groups of people have an answer to this common question. The Greek myths declare that only Geia (the Earth) and a great sea of Chaos were in the beginning, and in a soap opera fashion the gods eventually came forth, who eventually created humans (Bierlein 47-8). The Chippewa/Algonquin Native Americans believe that the great Earth Mother had two sons, a good one and a bad one that ended up creating the plants, animals, and humans (61). In the Christian, scientific Western Hemisphere, we believe in two possible answers -- one, that we descended from Adam, who was created from the mingling of the dirt of the ground with God's breath into His image (a doctrine held by religious Creationism), or two, that we evolved from monkeys which evolved from bacteria, which evolved from non-living chemicals and lightning (the scientific theory of evolution). These two theories both have credibility - the Bible is one of the oldest and most extensive historical documents we have, recorded with great precision, while evolution is very logical and builds on numerous scientific disciplines. Yet creation and evolution seem diametrically opposed. If we were created randomly and purposelessly, as evolution suggests, then the creation account of a sculptor molding his clay to make man appears erroneous. So scientists often call the Genesis account a â€Å"myth† – a story conceived by early man to explain away his questions. Christians are often offended by implications like these, and end up attacking science’s claims. In turn, many scientists feel distaste for people who don't accept their elegant theory and their mounds of evidence, and thus reject the others' view. Though a war has been established pinning these two theories against each other, this dichotomy is actually a false one. Christians do not need to give up their faith and scientists can start believing in God. These two clashing but persuasive theories, creation and evolution, can be reconciled. First, these theories need to be defined. Definition Evolution is the theory that all living organisms can be traced back to a common ancestor, which came into being from non-living elements, by natural laws. Darwin’s contribution to this theory was the mechanism by which species could evolve – natural selection.

Letter of Inquiry

   Dear Or alternately: Dear Sir/Madam: I have been informed of a job opportunity as IPRO Management and Technical Support Engineer by [name of referrer/optional]. I am a very interested in such a position because [qualifications or related work & interests/bulleted type lists of qualifications if possible]. I am currently employed at [name of organization] as [title of position]. Or alternately: I have just finished my Bachelor’s degree in the Multidisciplinary Studies with concentrations – Mechanical Engineering, Packaging Science, and Management Studies from [name of academic organization]. I believed my academic competencies would match qualification requirements of aforementioned position. I am looking forward to further discuss this job opportunity and how I can be a part of the success of Stratosphere, Inc. Sincerely,    One final way to be noticed the reader and to show a personal touch is by adding a post script or PS to your letter personally handwritten if at all possible.(â€Å"Cover letter advice†, 2007) Reference: Cover letter advice. (2007).  Ã‚   Retrieved March 15, 2007, from http://www.cvtips.com/cover_letter_guide_3.html   

During protestant reformation

Henry Vic's people became angry with the church, and German monk Martin Luther spoke out (95 theses). B. The Elizabethan Era (p. 288) Elizabeth l, prove to be great ruler. Sent Sir Francis Drake across globe, and Sir Walter Raleigh tried to put colony in Virginia. Greatest feat is defeating the Spanish Armada. C. The Rise of the Stuart and The Defeat of the Monarchy (p. 289) After death of Elizabeth, James I took throne (Scotland). This angered Catholics after his support of Church of England. Charles I took over in 1625 and relations withPuritans worsened, also after he dismissed Parliament. This put England into civil war. Oliver Cromwell and puritans defeated Royalists. Puritans made a commonwealth. Big set back. Once Charles II came back from exile to assume the throne restoration began. D. The Renaissance (p. 290) Art, poetry, music, theatre, all thriving during this time period. Started in Italy and spread throughout Europe. Life on Earth began to hold more energy and interest than thoughts of afterlife and religion. A renaissance man was a well rounded man who did the best he could with his or her talents. This was the time of Shakespeare,Galileo, and other creative people who invented and developed things to cultivate time period. Such as compass, printing press, and things like that. People began to explore life on earth and began to question many important things. Theatre was huge during this time, and King James Bible was made. The time period concluded in 1660 II. Renaissance Literature A. Pastoral Poems and Sonnets (p. 291) Energy became vibrant in literature. Sir Phillip Sidney, Sir Walter Raleigh and Edmond Spencer all put forth great literature. A pastoral poem is one that represents an idealized manner of shepherd life. Literature of Nature also emerged evilly.B. Shakespearean Drama (up. 292-93) Shakespeare contributed so much to drama and literature during time period. Mystery, mystical and morality plays developed greatly. Interludes and Lati n and Greek dramas. He contributed tragedy and Comedies that to this day are famous. Also satires. His plays displayed many events and stories throughout history C. The Rise of Humanism (up. 294-95) Art, History, Philosophy and literature is what Humanists studied. English humanists were Erasmus, Sir Thomas More. Utopia was famous work of literature. Many translations also appeared. D. Spiritual and Devotional Writings (up. 295-96)King James Bible did more to mold English writing than anything. Scholar John Wickedly was scrutinized for his translation of spiritual scripture. King James Bible influenced John Million's â€Å"Paradise Lost†. Also puritan writer John Bunyan who was famous for his allegory arose during this time. E. The Metaphysical and Cavalier Poets (up. 296-97) Ben Johnson was an accomplished poet related to Shakespeare because of that manner or writing. Ben Johnson had a group of men who followed him called â€Å"Sons of Ben†, this included Robert Heroi c, Richard Lovelace, and Sir John Suckling. John Done represents the Metaphysical poets.

A General Anasthetic Drug Sciences Essay Example

A General Anasthetic Drug Sciences Essay Example A General Anasthetic Drug Sciences Essay A General Anasthetic Drug Sciences Essay A general anesthetic is best defined as a drug capable of bring oning a reversible loss of esthesis, consciousness and mobility. Diethyl ether, used by William Morton in 1846 to execute a painless tooth extraction was the first good documented historical instance of a general anesthetic being used for both its anodyne belongingss every bit good its anesthetic map. Prior to this, nevertheless, ethyl alcohol had been used for many old ages as a method of dulling the patients esthesiss before surgery. The mechanism behind the analgetic and amnestic effects of ethyl alcohol and other anesthetics has long been thought to affect a transition in map of neural membrane proteins, nevertheless, throughout history many erroneous theories have gained false acceptance and the precise mechanism of ethyl alcohol and modern general anesthetics still remains an issue of contention. It is ab initio of import to divide and clarify more clearly the actions of general anesthetics as both an analgetic, and an effector of both consciousness and mobility. To analyze the difference between hurting and nociception, we must ab initio understand the slightly intertwined terminology by specifying exactly what we mean by both footings. Essentially nociception specifically refers to the nervous procedures of encoding and treating noxious stimuli , in kernel the physiological determiner behind the esthesis of pain.1 The 1960 s work by R.Melzack and P.Wall was the first to set up the footing of our current position of hurting, mentioning controlled gate theory as the method behind nociception. In so making, their work rebutted the two traditional reciprocally sole theories of hurting ; specificity theory ( which envisioned hurting as a specific mode ) and pattern theory ( which claimed that hurting was a response to intense stimulation of non-specific receptors ) . It is of import to observe that the traditional theories behind the esthesis of hurting do besides try to analyze nociception but fail to adequately explicate the nervous mechanism. The Melzack-Wall gate control theory provinces that the substantia gelatinosa modulates the sensory nerve forms. In so making the theory was successful in incorporating afferent upstream procedures with motorial downstream transition from the brain.1 It is hard to pull a clear and precise differentiation between anesthetics and anodynes as many anesthetics have analgetic belongingss, although this differentiation is made clearer with general anesthetics as few, if any, anodynes cause loss of consciousness if administered in appropriate doses. Some general anesthetics are capable of straight decreasing station operation nociception by moving on neural membrane proteins ( see below ) , whilst others produce the consequence of cut downing hurting by slaking centripetal responses such as force per unit area, proprioception and heat. It has late been speculated that some general anesthetics may even increase station operative hurting and so redness ( e.g. propofol and etomidate ) .2 Ethanol is an interesting drug in footings of its belongingss as a general anesthetic. Historically ethyl alcohol was administered to persons as a signifier of hurting alleviation prior to operations and had the consequence of dulling esthesis. This was in fact non straight impacting the nociception in an single but instead apparently cut downing their degrees of hurting by by and large dejecting activity in the nervous system moving more as an anesthetic than an analgetic. . Ethanol neer produced the effects of modern general anesthetic drugs in worlds, nevertheless, it is still often used in research affecting other smaller animate beings, peculiarly invertebrates as a signifier of general anaesthetic.3 Ethanol is known to impact both the cardinal and peripheral nervous system and deject the activity of both. For the intent of general anesthetics the prevailing consequence of involvement is that on the spinal cord and the encephalon. Probes into anaesthetic belongingss of ethyl alcohol on the spinal cord in rats indicate that a reversible depression in excitant post-synaptic potencies ( glutamate, AMPA and NMDA receptors ) is induced upon disposal of an equal dosage. Furthermore, the slow ventral root potency ( NMDA + metabotropic receptors ) and the dorsal root possible ( GABAAreceptors, via glutamate-excited interneurons ) are besides diminished.3 These responses are really similar in consequence to those induced as a consequence of the inspiration of modern general anesthetics used in worlds and exemplify the depressive consequence ethyl alcohol can hold on NMDA and AMPA receptor mediated transmittal. In add-on, it has been indicated that augmentation of GABAergic transmittal is countermanded by the depression in activity of interneurons as a consequence of suitably high ethyl alcohol concentrations. This demonstrates that the mechanisms of action of ethyl alcohol are widespread and many different receptors are affected. Contemporaneous surveies into the consequence of ethyl alcohol ( when administered in measures below those capable of act uponing alterations in receptor binding ) in rat encephalons indicate a less generalized mechanism of action and suggest that specifically Gs protein map is affected via the suppression of camp formation. These surveies play down the axial rotation of ethyl alcohol in act uponing the map of Gi and Go proteins, every bit good as GABAB ( and its related signal transduction ) and the adenylate cyclase system.4 This was tested by handling membrane cysts with an acidic solution which was known to bring on suppression of the map of the Gs protein entirely. The depressive consequence of ethyl alcohol on camp formation was abolished. Despite this, ethyl alcohol is typically viewed as a general fluidizer of membranes and is merely effectual in doing general anesthesia in big doses. Small concentrations of ethyl alcohol cause no important alteration in membrane fluidness. This possibly indicates that ethyl alcohol reduces the esthesis of hurting by moving as an anesthetic which explains its usage as an early pain-killer or analgetic for operations. I use this phrase really slackly here, as its analgetic belongingss arise as a effect of its system-generalised anesthetic qualities.5,6 It is deserving adverting that there is, to this twenty-four hours, no unequivocal and universally accepted mechanism of action of general anesthetics. There are, nevertheless, several ab initio established theories that have now been mostly discredited. The work of Meyer and Overton independently were the first indicants that general anesthetic ( such as isoflurane ) authority might be associated with lipid solubility. They concluded that the greater the lipid solubility of a possible anesthetic in olive oil, the greater its authority ( Fig1 ) .7 This lipid action theory was furthered in 1973 by the work of Miller and Smith who theorised that big, hydrophobic anesthetic molecules aggregate within neural membranes and bring on enlargement of the membrane due to displacement. This was thought to bring forth an anesthetic consequence by reversibly altering the morphology of trans-membrane ion channels ( Fig2 ) . The suggestion was that the molecular volume was the critical constituent of an anesthetic as opposed to the chemical construction. This is known as the critical volume hypothesis and is supported by the force per unit area reversal consequence ( increasing atmospheric force per unit area diminishes the efficaciousness of general anesthetics ) .8 These two theories were mostly disproved for legion grounds. Most convincing rebuttals centre on the fact that the supposed changes in membrane denseness could likewise be produced by little alterations in organic structure temperature without arousing anesthesia. Furthermore, many really lipid soluble drugs did non move as anesthetics, and some stereoisomers, despite holding the same oil/gas divider coefficients had radically different anesthetic effectivity. Evidence suggests that there is a correlativity between authority of anesthetics and lipid solubility, nevertheless, these theories do nt bespeak a lipid mark site. This theory is based on the sensitiveness of specific trans-membrane ion channels to changes in the force per unit area within the membrane. Soluble general anesthetics that collect within the bilayer are thought to act upon this force per unit area, doing a alteration in the conformational equilibrium of ligand gated ion channels and other such proteins ( as mentioned in the subdivision on ethyl alcohols above ) . This mechanism suggests that the specifying factor in general anesthetic authority is determined by its stereochemistry non the chemical construction, or lipid solubility entirely. The theory is as follows: ab initio upon an reaching of an action potency the cross sectional country of a Na channel protein is increased on the bilayer surface more than in the center. However, the presence of the anesthetic in the bilayer, and the subsequent deformation of force per unit area near the extracellular sphere increases the likeliness of the ion channel to switch to the closed pro vince as greater work is required to get the better of the higher force per unit area at the interface ( Fig3 ) .9 The modern lipid hypothesis suggests that anesthetics do non straight act upon membrane protein marks, but instead interrupt the force per unit area in the protein-lipid bilayer that acts as a go-between. This is a different and fresh transduction mechanism. It is eventually deserving adverting that many scientists still believe that the current lipid hypothesis does non to the full explicate the mechanism behind the action of general anesthetics, and some believe that a more specific membrane protein hypothesis ( similar to that of ethyl alcohol ) holds the key to unknoting the precise mechanisms of action of general anesthetics.

By the way vs. As a matter of fact

By the way vs. As a matter of fact By the way vs. As a matter of fact By the way vs. As a matter of fact By Maeve Maddox A reader from Brazil asks for clarification on the expressions â€Å"by the way† and â€Å"as a matter of fact,† having heard that they are interchangeable expressions to be used when a person wants to change the subject of a conversation. by the way As one of its earliest meanings, the expression â€Å"by the way† had the literal meaning of â€Å"along the way† in the sense of something happening in passing on a journey. For example, â€Å"I lost my money by the way.† The use of â€Å"by the way† in conversation is figurative. A person thinks of something else while in the process of talking: We went to the Crystal Theater over the weekend to see Titanic. By the way, while we were there, we bumped into Leroy and his new girlfriend. The expression does introduce a new subject, but not as a deliberate ploy to change the subject. The new subject has been suggested by something already being talked about. as a matter of fact This expression means, â€Å"in fact, really, actually.† Its strongest use is to correct a falsehood or misunderstanding, as in this example: Most people probably believe that the actress Judy Holliday, who acted the part of a dumb blonde in Born Yesterday, was really of low intelligence. As a matter of fact, she had an IQ of 172. In its weakened use, â€Å"as a matter of fact† still means, â€Å"in fact† or â€Å"actually,† but not in the sense of correcting a falsehood. It seems to be used as one might say indeed for emphasis or contrast. Here are some examples from the Web: I asked my sister if she drank diet soda. She told me that she did. As a matter of fact, she was getting ready to crack one open that moment. At 12 years old, I wasn’t a fat kid. As a matter of fact, I was pretty skinny. The weight isnt going to instantly fly off in the first week. As a matter of fact, I gained weight before I started losing. I am doing so well in my health. As a matter of fact I have dodged several colds that my husband has come down with. Yes, you have to deal with co-workers. As a matter of fact, you have to interact with them daily. It is possible that someone uncomfortable with the turn a conversation has taken might use one of these expressions to introduce an entirely new topic, but that is not their general function. Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Expressions category, check our popular posts, or choose a related post below:Regarding Re:How to Pronounce Mobile48 Writing Prompts for Middle School Kids

Coke is good for our health or not Essay Example | Topics and Well Written Essays - 750 words

Coke is good for our health or not - Essay Example When I changed clients, the situation was a little different from the new client’s workplace. There was no soda to get hooked to. I resulted to carrying several cans to the workplace and even get into the same queues that I used to pride myself as not participating in. At this point, I was getting a little concerned about my Coke addiction, and I started searching online for the negative effects of not just Coke too much fructose corn syrup. It is while I was reading the effects of excess fructose corn syrup that I discovered that fructose can also serve as an alternative to beer and cane sugar. I later realized that the type of addiction that an individual can experience in terms of Coke drinking can almost match the type of addiction from an alcoholic addiction perspective. In my research, it became evident that Coke is not a good beverage as we are supposed to believe. The highly consumer friendly classifieds are nothing but marketing gimmicks aimed at gaining public support by portraying Coke as a healthy beverage. Of concern to me was that high fructose diet often converts into fat as compared to any other sugar. According to experts and the opinion I read online, this high conversion rate into fats is the major cause of weight gain. Just looking around, I could notice that a lot of people in the streets were overweight. More specific is that most people line in queues at fast-food joints displayed a similar character trait, that of being overweight. Could there be a connection between Coke addiction and weight gain? The answer is yes. One specific example from an online website detailed how the Diabetes Prevention Program at Louisiana State University Medical Center explained to International Congress on excess weight that it was the introduction of excess fructose corn syrup that obesity cases started to increase. In my